• The aim of this study was to

  2019-06-20

  

  The aim of this study was to determine the therapeutic relevance of blocking RANKL in Ewing\'s sarcoma by using OPG administered by non-viral gene transfer approaches in two models of human Ewing sarcoma in immunodeficient mice. OPG was administered using amphiphilic polymers constituted by blocks o

• The congruence between BrS and ERS

  2019-06-20

  

  The congruence between BrS and ERS with respect to clinical manifestations and response to therapy lends further support to the repolarization hypothesis. Using an experimental model of ERS, Koncz et al. [30]. recently provided evidence in support of the hypothesis that, similar to the mechanism ope

• A lo largo de todo el siglo abundan las

  2019-06-20

  

  A lo largo de todo el siglo abundan las obras literarias incitadas por la búsqueda y promoción de la originalidad del continente; en el terreno lírico, la del argentino Juan María Gutiérrez (1809-1878) se erige como una de las más genuinas expresiones de esta tradición americanista. No por mero az

• br Tara Mangal and colleagues document the struggle to

  2019-06-20

  

  Tara Mangal and colleagues document the struggle to eliminate polio in northern Nigeria. However, they overlook the importance of routine immunisation to polio eradication efforts. The investigators identified an association between the risk of contracting polio and oral polio vaccine unavailabil

• The concept of substrate mapping

  2019-06-19

  

  The concept of substrate mapping and ablation evolved from these surgical experiences. Unlike surgeons who can visually identify the infarct region, electrophysiologists must locate the abnormal region using the guidance of local ventricular electrograms. Marchlinski et al. reported that voltage map

• Racial ethnic differences should also be considered for the

  2019-06-19

  

  Racial/ethnic differences should also be considered for the effects of ASA. In the JAST (Japan Atrial Fibrillation Stroke Trial) in 896 Japanese patients with nonvalvular AF [22], the incidence of the primary composite endpoint (i.e., cerebral infarction, TIA, or cardiovascular death) was higher in

• br Methods br Results br Discussion Bisphosphonates reduce

  2019-06-19

  

  Methods Results Discussion Bisphosphonates reduce skeletal morbidity in patients with advanced cancers involving bone and have become a recommended component of the multidisciplinary treatment of MBD [1]. However, bone-health benefits have not generally translated into significantly improv

• syk inhibitors br Epigenetic regulation of genes involved in

  2019-06-19

  

  Epigenetic regulation of genes involved in hepatic lipid metabolism by S1P and SHP The signaling cascade of CBA > S1PR2 > SphK2 > S1P > HDAC1/2 > increased hepatic gene expression can differentially up-regulate blocks of genes involved in the hepatic metabolism of sterols and lipids (Fig. 3, Tabl

• Idelalisib demonstrates a dual mechanism of action

  2019-06-19

  

  Idelalisib demonstrates a dual mechanism of action by inhibiting pro-survival signalling pathways [6], and, like other kinase inhibitors, leads to re-localisation of tumour order SB 612111 hydrochloride by blocking ingress into and promoting egress out of the lymph node into the blood. Release from

• The studies from several laboratories suggest

  2019-06-19

  

  The studies from several laboratories suggest that miR-34 family members are the direct targets of TP53, and their upregulation can induce cancer cell apoptosis and cell-cycle arrest. It has been found that miR-34 is associated with prognosis, carcinogenesis, and survival of various cancers, includi

• In focal coronary spastic angina intravascular ultrasound wa

  2019-06-19

  

  In focal coronary spastic angina, intravascular ultrasound was reported to detect intima–media complex thickening and an increased sonolucent zone [16,17], and OCT can detect intimal thickening with low lipid and calcium deposits [18], which are believed to reflect neointimal hyperplasia subsequent

• The concept of metronomic chemotherapy began in the s when

  2019-06-19

  

  The concept of metronomic chemotherapy began in the 1990s, when Kerbel showed chemotherapeutic agents may be able to target tumor vessel endothelial cells. In 2000, Browder et al demonstrated a more frequent, lower dose of cyclophosphamide, i.e. anti-angiogenic schedule, could induce response in tum

• Numerous animal studies have demonstrated beyond doubt

  2019-06-19

  

  Numerous animal studies have demonstrated beyond doubt that effective inhibition of osteoclastogenesis or osteoclast function significantly reduces metastatic tumour growth in bone [13–20]. Likewise, clinical trials in patients with non-metastatic or metastatic cancers established that treatment wit

• br Clinical material br Discussion TLI is

  2019-06-19

  

  Clinical material Discussion TLI is regarded as a well-tolerated, simple procedure with few acute or late clinical sequelae reported. However, pulmonary irradiation as a therapeutic modality for metastatic bone sarcomas is, although introduced 30 years ago, insufficiently evaluated to clearly

• Parte de las idas y vueltas ten an

  2019-06-18

  

  Parte de las idas y vueltas tenían que ver con la negociación de un convenio sobre cooperación científico-técnica (suscrito el 27 de agosto de 1980), de uno financiero por un préstamo de 30 millones de dólares (firmado entre el 19 y el 24 de noviembre de 1980 entre el Banco Central argentino y el Ba

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