• br Introduction Clinical manifestations of

  2024-05-13

  

  Introduction Clinical manifestations of Alzheimer's disease (AD) are mainly characterized by progressive intellectual deterioration, memory impairment, cognitive impairment, and psychiatric symptoms. The pathogenesis of AD remains unclear, mainly containing genetic factors, neurotransmitter disor

• Does dietary caffeine interfere with antinociception by othe

  2024-05-13

  

  (8) Does dietary caffeine interfere with antinociception by other modalities that alter pain (TENS, exercise, joint mobilization, water immersion therapy)? Caffeine and/or A1R antagonists inhibit antinociception by each of these modalities in preclinical studies, such that there is potential for int

• br Conclusions Several lines of evidence have been

  2024-05-13

  

  Conclusions Several lines of evidence have been established, which support the adenosine kinase hypothesis of epileptogenesis, which is based on a sequence of events leading from acute RTA-408 injury to initial downregulation of ADK, rise in extracellular adenosine, changes in astrocytic adenosi

• br Acknowledgment br Introduction Vascular

  2024-05-13

  

  Acknowledgment Introduction Vascular smooth muscle cells (VSMC) exhibit the capacity to switch between a differentiated (contractile) and a dedifferentiated (synthetic) phenotype [1]. Synthetic VSMC express a lower amount of contractile proteins such as Smooth muscle 22α (sm22α) and α-Smooth m

• Our analysis has devoted limited attention

  2024-05-13

  

  Our analysis has devoted limited attention to the standard corporate tax scheme with deductibility for interest payments that is in place in most countries. A conventional corporate tax scheme offers partial deduction of capital costs, and can be interpreted as a change in the degree of capital cost

• By performing knockdown of AXL once HER cancer

  2024-05-13

  

  By performing knockdown of AXL once HER2+ cancer YM178 receptor have achieved lung colonization, we demonstrated that AXL contributes to the establishment of macrometastases. While inhibition of AXL impairs the efficiency of metastasis, the later finding has major clinical implications since pharma

• pitavastatin br Role of autophagy in alcoholic

  2024-05-13

  

  Role of autophagy in alcoholic cardiomyopathy Concluding remarks The genetic and phenotypic heterogeneity in alcoholic cardiac injury has been recognized despite the seemingly beneficial effects of low to moderate alcohol consumption [8]. Although oxidative stress is well established in the pa

• Pompe disease is accompanied by

  2024-05-13

  

  Pompe disease is accompanied by the deficiency of the lysosomal α-1,4-glucosidase that makes the Bikinin unable to hydrolyze glycogen to glucose, thereby resulting in the accumulation of glycogen in lysosomes, especially in skeletal muscles and cardiac tissues. This accumulation results in the stru

• Several mechanisms have been suggested

  2024-05-13

  

  Several mechanisms have been suggested to account for the causal association of ICAM-1 induction and leukocyte adhesion with DR, including oxidative stress [16], NF-κB [17], PKC [18], and bioactive lipids [19]. Our previous studies highlighted the role of bioactive lipid metabolites derived from 12/

• GSK343 AP activation is known to upregulate downstream targe

  2024-05-13

  

  AP-1 activation is known to upregulate downstream target genes including GSK343 D1, c-myc, Bcl-xl, MMP-9, EGFR, and specific miRNAs that are involved in progression and metastasis of tumors. Moreover, matrix metalloproteinase-2 has been shown as a downstream gene of AP-1, triggered by 15-HETE in th

• The protective role of HMW

  2024-05-11

  

  The protective role of HMW-HA in inflammatory diseases and pulmonary damage led us to investigate whether PM2.5-induced ALI could be attenuated by HMW-HA and the underlying mechanisms. In this study, we used a rat model to evaluate the effect of HMW-HA on pulmonary histology, lung inflammation, oxid

• Cilnidipine The physiologic conditions and signaling mechani

  2024-05-11

  

  The physiologic conditions and signaling mechanisms that regulate apelin secretion and APLNR expression in malignant tissues appear to be multifactorial. Previous studies have shown that hyperplastic and neoplastic cholangiocytes secrete a variety of hormones, peptides, and growth factors that help

• br Material and methods br Results

  2024-05-11

  

  Material and methods Results Discussion Didox was originally created asa cytostatic drug to inhibit cancer cell proliferation by antagonizing RNR [11]. When used to target highly proliferative cells, Didox has extensive activity in vitro and in vivo. It has also been employed in clinical st

• transcription factors Glycosylphosphatidylinositol GPI cell

  2024-05-11

  

  Glycosylphosphatidylinositol (GPI) transcription factors anchor synthesis pathway is another promising antifungal target. Novel inhibitors of Gwt1 and Mcd4, two enzymes in the GPI anchor pathway were identified by the chemical-genomics-based screening platform CaFT (Candida albicans fitness test) [

• br The lipoxygenase pathway in vascular physiology and patho

  2024-05-11

  

  The 12/15-lipoxygenase pathway in vascular physiology and pathology The mammalian 12- and 15-LOXs have high substrate specificity oxidizing predominantly ω−6 (arachidonic and linoleic acids) but also the ω−3 (docosahexanoic) cysteine protease inhibitors [86], [87], [88]. Different LOXs oxidize fa

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