• Harnessing the L1023 Anti-Cancer Compound Library for Nex...

  2025-09-28

  Explore how the L1023 Anti-Cancer Compound Library advances cancer research through high-throughput screening of cell-permeable anti-cancer compounds and accelerates molecular target discovery. This article uniquely dissects translational strategies for integrating compound libraries with emerging biomarker-driven oncology.

• Anti Reverse Cap Analog (ARCA): Unlocking Efficient mRNA ...

  2025-09-27

  Explore how Anti Reverse Cap Analog, 3´-O-Me-m7G(5')ppp(5')G, advances synthetic mRNA capping for superior translation and stability. This article reveals the unique impact of ARCA in next-generation mRNA therapeutics and stem cell reprogramming.

• Pifithrin-α (PFTα): Precision Modulation of p53 in Apopto...

  2025-09-26

  Explore how Pifithrin-α, a leading p53 inhibitor, enables targeted modulation of apoptosis, cell cycle arrest, and ferroptosis in advanced research. This article uniquely examines Pifithrin-α’s role in neurotoxicity models and stem cell regulation, offering unparalleled depth for p53 pathway investigations.

• Biotin-tyramide: Precision Signal Amplification for Neuro...

  2025-09-25

  Explore how Biotin-tyramide enables ultra-precise signal amplification in neurodevelopmental research, surpassing standard tyramide signal amplification reagents in sensitivity and spatial resolution. This article uniquely integrates advanced mechanistic insights and applications in developmental neuroanatomy.

• Torin2: Redefining mTOR Inhibition and Apoptotic Signalin...

  2025-09-24

  Discover how Torin2, a highly selective mTOR inhibitor, unveils new mechanisms of protein kinase inhibition and apoptosis beyond transcriptional regulation. This article provides an advanced analysis of Torin2’s unique role in mTOR signaling pathway inhibition, offering fresh insights for cancer research.

• Gastrin I (human): Enabling Advanced GI Physiology Modeli...

  2025-09-23

  Explore the critical role of Gastrin I (human) as a gastric acid secretion regulator in cutting-edge gastrointestinal physiology studies. This article highlights its applications in organoid-based research and receptor-mediated signal transduction for gastrointestinal disorder research.

• br Acknowledgments br Introduction Within the classical secr

  2025-03-03

  

  Acknowledgments Introduction Within the classical secretory pathway, transmembrane and soluble cargos travel via the endoplasmic reticulum (ER) and Golgi apparatus en route to their final destinations [1]. However, at a post-Golgi level, trafficking routes can diverge. In this context, the tra

• We have previously shown that the antinociceptive effect of

  2025-03-03

  

  We have previously shown that the antinociceptive effect of tramadol, an analgesic that, like paracetamol is able to increase serotonin levels within CNS, is potentiated or antagonized respectively by a 5-HT1A/B nonspecific gli1 blockade or activation (Rojas-Corrales et al., 2000). Moreover, it has

• HT receptors are distributed throughout the brain within the

  2025-03-03

  

  5-HT3 receptors are distributed throughout the brain, within the brainstem (e.g., nucleus tractus solitarius, area postrema and spinal trigeminal nucleus) and thiostrepton synthesis (e.g., hippocampus, amygdala, nucleus accumbens, putamen and caudate) (Abi-Dargham et al., 1993, Barnes et al., 1989,

• ADOR immunoreactivity was high in parasympathetically innerv

  2025-03-03

  

  ADOR immunoreactivity was high in parasympathetically-innervated smooth muscle, namely the iris sphincter muscle and the ciliary muscle. No ADOR immunoreactivity was noted in the sympathetically-innervated iris dilator muscle. Immunoreactivity against all four ADORs was noted in the ciliary epitheli

• Diabetes or inflammation is associated with up regulation of

  2025-03-03

  

  Diabetes or inflammation is associated with up-regulation of A2AAR (Pang et al., 2010). High levels of A2AARs are found in macrophages and microglial cells that are poised, on activation, to abrogate the immune response (Trincavelli et al., 2008). In addition, hyperglycemia is associated with increa

• Endocytosis inhibition The rapidity of this specific immunos

  2025-03-03

  

  The rapidity of this specific immunosuppressive therapy suggests that it inhibits or apoptoses plasma cells. Most serum autoantibodies to AChR are produced by long-lived plasma cells residing in spleen and bone marrow. These terminally differentiated cells are resistant to most non-specific immunosu

• Although our data failed to reproduce the robust enhancement

  2025-03-03

  

  Although our data failed to reproduce the robust enhancement of LTP in the rat dentate with nicotine that was previously reported, our results with NS6740 suggest a more fundamental role for α7 receptor signaling in modulation of synaptic tone in the LTP pathway. The discovery of the cholinergic ant

• Finally Urban Ciecko et al asked whether this

  2025-03-03

  

  Finally, Urban-Ciecko et al. (2018) asked whether this enhancement is specific to the pyramidal to SST neuron synapses or more generally observed in other synapses of the cortical microcircuit. Synapses between pyramidal cells showed no sign of potentiation after either bath application of the choli

• br Materials and methods br Results br Discussion Despite

  2025-03-01

  

  Materials and methods Results Discussion Despite the relative complexity of immunotherapy, such treatment may have an important role, in conjunction with other therapies in the treatment of cancer refractory to conventional treatments alone. Clinical studies have recently shown that adding

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