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The concept of metronomic chemotherapy began in the s when
2019-06-19
The concept of metronomic chemotherapy began in the 1990s, when Kerbel showed chemotherapeutic agents may be able to target tumor vessel endothelial cells. In 2000, Browder et al demonstrated a more frequent, lower dose of cyclophosphamide, i.e. anti-angiogenic schedule, could induce response in tum
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Numerous animal studies have demonstrated beyond doubt
2019-06-19
Numerous animal studies have demonstrated beyond doubt that effective inhibition of osteoclastogenesis or osteoclast function significantly reduces metastatic tumour growth in bone [13–20]. Likewise, clinical trials in patients with non-metastatic or metastatic cancers established that treatment wit
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br Clinical material br Discussion TLI is
2019-06-19
Clinical material Discussion TLI is regarded as a well-tolerated, simple procedure with few acute or late clinical sequelae reported. However, pulmonary irradiation as a therapeutic modality for metastatic bone sarcomas is, although introduced 30 years ago, insufficiently evaluated to clearly
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Parte de las idas y vueltas ten an
2019-06-18
Parte de las idas y vueltas tenían que ver con la negociación de un convenio sobre cooperación científico-técnica (suscrito el 27 de agosto de 1980), de uno financiero por un préstamo de 30 millones de dólares (firmado entre el 19 y el 24 de noviembre de 1980 entre el Banco Central argentino y el Ba
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He querido citar este pasaje del art culo de Eudocio
2019-06-18
He querido citar este pasaje del artículo de Eudocio Becerra para mostrar cómo, sin quererlo, esta manera occidental de abordar la cuestión del estatuto ontológico y epistemológico que la palabra tiene para los uitotos, conduce al mismo callejón sin salida en el que desembocaron los estudios que él
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br Prognosis The management of AML in the elderly patient
2019-06-18
Prognosis The management of AML in the elderly patient presents a significant challenge for hematologists. Careful evaluation of both patient and disease is required in each individual case to make optimal management decisions, and maximize the benefit to the patient. Apart from the extremely old
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For many years international donors philanthropists and
2019-06-18
For many years, international donors, philanthropists, and charities have poured money into deworming programmes for children in low-income and middle-income countries in the belief they will contribute to improved health, school performance, and economic development. The Rockefeller Sanitary Commis
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Chronic hepatitis B virus HBV infection
2019-06-18
Chronic order 6-Hydroxydopamine hydrobromide virus (HBV) infection is prevalent in many Asian countries, notwithstanding three decades of universal hepatitis B vaccination programs. The invention of nucleos(t)ide analogs (NUCs) was a breakthrough in the treatment of chronic hepatitis B (CHB). Howev
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Three possible mechanisms may underlie the decrease in the n
2019-06-18
Three possible mechanisms may underlie the decrease in the number of PVBs in the present patient: the first is the antiarrhythmic action of Omacor, the second is the natural time course of PVBs, and the third is the day-to-day variability in the number of PVBs. Therefore, we performed an additional
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Besides the possibility of a tumor
2019-06-18
Besides, the possibility of a tumor with spontaneous regression seem not to be associated with tumor size, tumor number, the level of serum alpha-fetal protein presence or not of distance metastasis distance metastasis. Two common mechanisms of HCC with spontaneous regression were suggested: tumor h
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In the phase AZURE trial women were
2019-06-18
In the phase 3 AZURE trial, 3360 women were randomly assigned to receive standard adjuvant systemic treatment alone (control group) or with 4mg intravenous zoledronic A 967079 every 3–4 weeks for 6 doses, then every 3 months for 8 doses, followed by every 6 months for 5 doses, for a total of 5 year
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Data for each assessment point are expressed
2019-06-18
Data for each assessment point are expressed as the mean value plus standard deviation. One tailed paired t-tests were performed to analyze the effects of ibandronate treatment. Significance level was set at p Results The study included 33 patients with a variety of different primary tumors (Table
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purchase L-Arabinose LQT can have numerous clinical manifest
2019-06-18
LQT1 can have numerous clinical manifestations, ranging from no symptoms to sudden cardiac death, which reflects the heterogeneity in channel dysfunction. Mutation type, location, and even a patient׳s ethnic background, age, and gender are critical factors that affect the pathophysiology of the dise
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Proteinase K The aim of this cross sectional
2019-06-18
The aim of this cross-sectional study was to investigate the relationships between patient characteristics and antithrombotic therapy prescribed for the prevention of ischemic stroke and systemic embolism in patients with NVAF in clinical practice. Additionally, because the data were to be used to c
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El juego de las apariencias y la obtenci
2019-06-18
El juego de las apariencias y la obtención de un estatus no son privativos de los consumidores del arte en este texto: coleccionistas, guías de museo o críticos improvisados. El cuento “Borges y el ultraísmo”, también del libro Amores de segunda mano (1991), ubicará la discusión directamente en los
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